Updated: Jun 30
Brand new to CBG? This is an ever-growing guide on all things CBG! From uses and benefits, right the way through to extraction and strains.
Cannabidiol (CBD) has become very popular among mainstream consumers. Cannabigerol (CBG), on the other hand, seems like a good alternative or, better yet, a good addition to CBD- and THC-based products for both medical and recreational use.
Cannabigerol is getting more attention from researchers, producers, and consumers because it is a cannabinoid that doesn't make people high. Because it is getting a lot of attention, our full guide to cannabigerol answers all your questions about this new cannabinoid.
What is (CBG) Cannabigerol?
Cannabigerol (CBG), which was first found in 1964 and is called the "mother of all cannabinoids," is an amazing compound with a lot of therapeutic potentials. It is only one of more than 100 cannabinoids that can be found in cannabis. Cannabigerol acid (CBGA), its acidic form, is the building block of many other major and minor cannabinoids.
CBGA is an acidic chemical that is the starting point for three main compounds:
Tetrahydrocannabinolic acid (THCA)
Cannabidiolic acid (CBDA)
Cannabichromenic acid (CBCA)
As the cannabis plant grows up, a group of enzymes break down CBGA to make these three main cannabinoids. Most of the CBGA has turned into THCA, CBDA, and CBCA by the end of the harvest. Any extra CBGA can be turned into CBG by a process called decarboxylation. Cannabigerol boils at a temperature of 125.6°F (52°C).
CBD and delta-9 tetrahydrocannabinol (THC), which makes you feel high, are both found in high amounts in a mature cannabis plant. On the other hand, CBG is only present in very small amounts (less than 1% by dry weight). CBD-rich strains can have anywhere from 20% to 25% CBD. THC-rich strains can have anywhere from 25% to 30% THC.
Most cannabis plants have very small amounts of CBG, so natural products made from it aren't sold as often as THC and CBD products. But as interest in this amazing cannabinoid grows, so does research into how it can help people.
How CBG Works
CBG works with the endocannabinoid system in the body (ECS). The endocannabinoid system is in charge of keeping many important biological processes, like mood, sleep, memory, hunger, reproduction, and immune responses, in balance.
The ECS is made up of CB1 and CB2 cannabinoid receptors, which are found all over the body. Most of the time, CB1 receptors are found in the brain and nervous system. Most of the CB2 receptors are in the immune system.
Cannabigerol, in particular, binds to both receptors and amplifies the effects of anandamide, a neurotransmitter known as the "bliss molecule" that affects motivation, appetite, sleep, pleasure, and pain.
CBG is a CB1 receptor agonist, which means it interacts with the receptor and raises the amount of anandamide (AEA) in the nervous system. CBG can also interact with CB2 receptors in the gut and immune system. Researchers are not sure if it is an agonist or an antagonist for CB2.
Scientists have found that CBGA can have an effect on 5HT1A-receptors. This receptor controls how much serotonin is in the body. CBG can block the receptor to a small degree, which can change how serotonin works in the central nervous system.
Also, it has been shown that CBG acts on adrenoceptors. This helps it control how the central nervous system makes noradrenaline and adrenaline. In the sympathetic nervous system, adrenaline and noradrenaline are two of the most important neurotransmitters (SNS).
CBG has the following medical benefits, but it doesn't get you high like THC does.
CBD and CBG may be mixed up by many new users. CBG has many of the same health benefits as CBD. Both CBG and CBD have a lot of potential to treat a wide range of conditions and symptoms without getting you high. CBG and CBD do not make you feel high like THC does. They may also make THC less likely to make you feel bad.
CBD and CBG have different amounts. In the early stages of plant growth, CBGA is the main cannabinoid. Over time, it changes into CBDA, THCA, and CBCA. CBD-rich flower buds can have as much as 25% CBD, but CBG levels are usually less than 1%. Related Article: The High Committee Guide To CBG
Possible Benefits of CBG
CBG vs CBD
Cannabigerol has shown itself to be a good addition to the non-psychoactive cannabidiol. Early studies of this cannabinoid are very promising, but more human studies that are peer-reviewed are still needed to show how well it works. Future research can start to find out what the compound can really do.
CBG VS Inflammatory Bowel Disease (IBD)
IBD, or inflammatory bowel disease, is a chronic inflammation of the digestive tract. It includes Crohn's disease and ulcerative colitis. In a 2013 study on animals, CBG was found to reduce inflammation and the production of nitric oxide in the colons of mice. It also stopped the body's intestines from making reactive oxygen species (ROS).
CBG VS Bacterial Infections
A 2020 study found that CBG is very good at killing bacteria. CBG worked well against strains of staphylococcus aureus that were resistant to methicillin (MRSA). MRSA is known for causing staph infections that are hard to treat because they are resistant to drugs.
Glaucoma & CBG
In a study done on animals in 2008, it was found that cannabigerol helped treat glaucoma. Researchers found that cannabigerol lowered eye pressure and increased the flow of aqueous humour, a fluid that helps keep eye pressure steady and feeds the eye.
CBG VS Huntingdon Disease
Huntington disease is a rare condition that is passed down from parent to child. It causes nerve cells in the brain to die. In a study done in 2015, CBG and other cannabinoids were given to mice with an artificial version of Huntington's disease.
In the study, CBG worked as a neuroprotective compound that kept damage from happening to nerve cells in the brain. In addition to protecting neurons, it also fixed motor problems and kept striatal neurons from being hurt by 3-nitropropionic acid.
CBG VS Colon Cancer
In a study done in 2014, researchers found that CBGA slowed the growth of colon cancer tumours in mice. CBG stops the growth of cancer cells in the colon by blocking TRPM8 channels that help cancer cells grow. It also stopped colorectal cancer cells from being made.
CBG: Appetite Stimulant
In 2016, a study on rats found that CBG made the rats hungry. When rats were given CBG, they were able to eat twice as much as rats in the control group. Stimulating the appetite can help HIV patients who are having trouble eating or who have lost their appetite because of chemo.
CBG VS Bladder Dysfunction
In 2015, a study looked at how many different cannabinoids affect the way the bladder contracts. Researchers found that CBG was the best cannabinoid for treating bladder problems. THCV, CBD, and CBDV were the next best.
High CBG Strains
Today, you can get more than just flower buds that are high in THC and CBD. CBG strains aren't as common as THC buds, but more and more dispensaries are carrying them. Hemp has more CBG than cannabis strains that are high in THC.
Popular CBG strains include:
Super Glue CBG
CBG Jack Frost
CBG Desert Snow
There are more CBG products on the market than ever before, especially in oil form. Still, compared to other cannabinoid oils, CBG oils are expensive and hard to come by.
Common CBG Products:
CBG Hemp Flowers
CBG Gum to Chew
CBG Under-the-Tongue Tablets
Full-spectrum or broad-spectrum products contain all of the cannabinoids and terpenes that are found in cannabis plants.
- Broad-spectrum CBD products contain all of the cannabinoids except for THC.
- Full-spectrum cannabis products have all of the chemicals that the strain has, including THC.
The entourage effect is the way that cannabinoids work together to boost the positive effects of cannabis while reducing the negative side effects.
How CBG Is Grown & Extracted
After the 2018 Farm Bill was signed into law, it became legal to grow hemp and make things like cannabigerol from hemp. But the plant and anything made from it must have less than 0.3% THC.
CBG-rich biomass can be turned into cannabigerol oil with hydrocarbon, ethanol, or CO2 extraction methods.
Since CBGA is the first cannabinoid to form in young cannabis plants, growers must harvest hemp plants quickly. Growers should wait until six weeks into the eight-week flowering cycle to pick their plants. Before it changes into a number of other cannabinoids, CBGA levels will be the highest.
Cannabigerol is a minor cannabinoid that is only found in trace amounts in harvested cannabis. This means that CBGA levels will be frustratingly low, even if you harvest when cannabigerol levels are at their highest. Even worse, when you harvest young cannabis plants, you get less cannabinoids by weight than when you harvest mature cannabis plants.
Basically, there will need to be more biomass to make enough cannabigerol for commercial use. Cannabigerol-based products are more expensive than other cannabinoid-based products because they are more difficult to make.
Breeders have used genetic manipulation and crossbreeding to make cannabis strains with higher concentrations of this cannabinoid in order to get higher yields. This makes extraction cheaper for both the people who make it and the people who buy it. At the moment, some hemp can have more than 90% CBG. Researchers think that a broken gene stops CBG from being turned into THC, which leads to higher concentrations.
How cannabinoids besides CBD and THC can help
CBD and THC are well-known cannabinoids that have earned their place among alternative treatments that are often used and have few side effects. As scientists learn more about how small parts of the plant can be used to treat diseases, they can make better products that boost the healing power of the plant.
I hope you found this guide to be useful. We will be updating this guide very often in order to make it truly the definitive guide to CBG, so be sure to check back! If you have any questions, feel free to drop a comment and we will certainly answer you! Thanks!